Projects

Our research projects focus on developing and applying AI and NLP technologies to solve critical challenges in healthcare.

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PittTron

Topics:
Clinical NLP LLM Application
Project Lead: Chenyu Li

A Large Language Model Trained on University of Pittsburgh Medical Center Electronic Health Records

ENACT NLP

Topics:
Clinical NLP
Project Lead: Chenyu Li

Development and Validation of Natural Language Processing Algorithms in the ENACT National Electronic Health Record Research Network

Large Language Models for Clinical Research Informatics

Topics:
Clinical NLP LLM Application
Project Lead: Min Gu Kwak

Investigate how large language models could accelerate clinical research informatics infrastructure development.

ReDWINE

Topics:
Clinical NLP
Project Lead: Min Gu Kwak

A clinical informatics data warehouse for rehabilitation care and research.

Safety of Large Language Models in Healthcare Applications

Topics:
LLM Alignment
Project Lead: Hang Zhang

Measuring the safety of LLMs in healthcare

Reinforcement learning for Large Language Models

Topics:
LLM Alignment
Project Lead: Hang Zhang

Investigate new reinforcement learning frameworks for LLMs

AI and Precision Nutrition

Topics:
Precision Nutrition
Project Lead: Xizhi Wu

Investigate how AI has been used in precision nutrition

Generative AI for Medical Education

Topics:
LLM Application
Project Lead: Mariano De Leon

Investigate how generative AI will impact and advance medical education?

Precision Rehabilitation

Topics:
LLM Application Clinical NLP

Use data-driven approach to identify the precision rehabilitation approaches that could result in optimal clinical outcomes

Generative AI for Assisting People with Disabilities

Topics:
LLM Application
Project Lead: Mariano De Leon

Investigate how generative AI will assist people with disabilities?

Generative AI for Pathology

Topics:
Foundation Models LLM Application

Generative AI technologies to advance clinical pratice in pathology using pathology images and EHRs

Evaluation Frameworks for Large Language Models in Healthcare Applications

Topics:
LLM Evaluation
Project Lead: Thomas Tam, Sonish Sivarajkumar

Evaluation needs to be standardized and comprehensive before the adoption of LLMs in healthcare

Large Language Models for Drug Discovery

Topics:
LLM Application
Project Lead: Averil Ludwick

Designing creative LLM-based approaches to facilitate drug discovery.

Generative Deep Patient

Topics:
Foundation Models LLM Application Clinical NLP
Project Lead: Sonish Sivarajkumar

Foundational AI models and large language models for generative patient embeddings using EHRs

Precision Oncology

Topics:
Cancer Informatics Clinical NLP
Project Lead: Sonish Sivarajkumar

NLP and ML algorithms to predict immunotherapy response and metastases prediction on lung adenocarcinoma patients.

Cancer NLP

Topics:
Clinical NLP Cancer Informatics
Project Lead: Xizhi Wu

NLP to extract social determinants of health information from ontology progress notes.

AI Agentic Systems for Clinical Oncology

Topics:
AI Agents Cancer Informatics
Project Lead: Praz Nagarajan

Build Multi-agent AI systems for intelligent clinical oncology care.

Multi-agentic AI for Headache Referral

Topics:
Clinical NLP AI Agents
Project Lead: Xizhi Wu

Build Multi-agent AI systems for automated headache referral.